PENGARUH PELARUT DEEP EUTECTIC SOLVENT ASAM DAN PROFIL METABOLIT EKSTRAK DARI KULIT BATANG SAGU (Metroxylon sagu Rottb. L)

Authors

  • Ulfah Zakiyah Hamdani Universitas Cokroaminoto Palopo
  • Rosmalah Yanti Universitas Cokroaminoto Palopo
  • Riska Riska

Keywords:

Acidic Solvent, Deep Eutectic Solvent, Profil Metabolit, Limbah Kulit Batang Sagu, LC-MS, Pelarut asam

Abstract

Telah dilakukan identifikasi senyawa yang terdapat dalam ekstrak Deep Eutectic Solvent (DES) asam dari kulit batang sagu (Metroxylon sago Rottb. L) menggunakan metode LC-MS. Studi meliputi tiga tahapan yaitu sintesis DES Kolin Klorida—Asam Oksalat (rasio molar 1:2) pada suhu 50°C (850 rpm), ektraksi bubuk kulit batang sagu memakai metode sonikasi (40W; 5, 15 & 30 menit; 30°C) dengan pelarut DES, serta karakterisasi dengan LC-MS. Berdasarkan hasil identifikasi, terdapat 73 senyawa dimana terdapat 54,75% diantaranya merupakan senyawa hidrokarbon alifatik, dan 72,60% diantaranya memiliki gugus fungsi N. Semakin lama waktu sonikasi, semakin banyak senyawa fragmen bergugus fungsi N yang teridentifikasi. Terdapat 6 senyawa ekstrak yang memiliki sifat khas antara lain sebagai agen antikanker, repellant, anti-inflamasi, fitohormon, inhibitor biosintesis kolesterol dan bahan aktif produk perawatan kulit wajah.

 

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References

[1] P. Lestari, W. T. Istikowati, Sunardi, D. Y. Y. Heri, W. Fatiasari, and R. S. Ningrum, “ANALISIS KANDUNGAN KIMIA KULIT BATANG SAGU (Metroxylon sagu Rottb.) SEBAGAI BAHAN BAKU PULP DAN KERTAS,” Jurnal Sylva Scienteae, vol. 05, no. 2, pp. 187–193, 2022, doi: https://doi.org/10.20527/jss.v5i2.5371.

[2] U. Z. Hamdani and R. Yanti, “Antioxidant Candidates in Deep Eutectic Solvent Extract of Choline Chloride-Oxalic Acid from Sago Bark (Metroxylon sagu L. Rottb),” J. Chem. Sci, vol. 14, no. 1, 2025, [Online]. Available: http://journal.unnes.ac.id/sju/index.php/ijcs

[3] M. Dinata, L. D. Putri, and F. Soehardi, “Diversity and use of Sago (Metroxylon sagu Rottb.) from Meranti Islands as Road Reinforcement,” Res. Sq., vol. March, pp. 1–14, 2023, doi: https://doi.org/10.21203/rs.3.rs-2632151/v1.

[4] W. T. Istikowati et al., “CHEMICAL CONTENT AND ANATOMICAL CHARACTERISTICS OF SAGO (Metroxylon sagu Rottb.) FROND FROM SOUTH KALIMANTAN, INDONESIA,” Indonesian Journal of Forestry Research, vol. 10, no. 2, pp. 185–194, 2023, doi: 10.59465/ijfr.2023.10.2.185-194.

[5] S. Khan, M. M. Khan, Badruddeen, U. Ahmad, and S. Khan, “Fisetin as a multifunctional bioactive flavonoid: A comprehensive review of its pharmacology, mechanism of action, safety profile, clinical trials, and future directions in therapeutics,” Food Biosci., vol. 73, p. 107620, Nov. 2025, doi: 10.1016/J.FBIO.2025.107620.

[6] C. Zhou, Y. Huang, S. Nie, S. Zhou, X. Gao, and G. Chen, “Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent,” Eur. J. Med. Res., vol. 28, no. 1, Dec. 2023, doi: 10.1186/s40001-023-01271-8.

[7] K. O. Murray et al., “Intermittent Supplementation with Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle with Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches,” Aging Cell, vol. 24, no. 8, Aug. 2025, doi: 10.1111/acel.70114.

[8] M. M. Barrozo et al., “Repellent Activity of the Botanical Compounds Thymol, Carvacrol, Nootkatone, and Eugenol Against Amblyomma sculptum Nymphs,” Pathogens, vol. 14, no. 9, Sep. 2025, doi: 10.3390/pathogens14090926.

[9] Y. L. You and H. S. Choi, “Nootkatone (NK), a grapefruit-derived sesquiterpenoid, suppresses UVB-induced damage by regulating NRF2-HO-1 and AhR-CYP1A1 signaling pathways in HaCaT cells,” Food Sci. Biotechnol., vol. 34, no. 8, pp. 1751–1761, Apr. 2025, doi: 10.1007/s10068-024-01791-x.

[10] T. Feng et al., “The protective role of muscone in the development of COPD,” Front. Immunol., vol. 16, 2025, doi: 10.3389/fimmu.2025.1508879.

[11] L. Li, S. Zhuang, and S. Jiang, “Muscone inhibits the progression of atherosclerotic plaques in mice aorta by inhibiting the NF-κB/p65 pathway,” Biochem. Biophys. Res. Commun., vol. 702, p. 149628, Apr. 2024, doi: 10.1016/J.BBRC.2024.149628.

[12] B. A. Rather, I. R. Mir, M. Mahajan, F. Qiao, X. Jiang, and M. I. R. Khan, “Jasmonic acid crosstalk with secondary metabolites and plant growth regulators to maintain redox balance during crop improvement under salt stress,” Plant Science, vol. 371, p. 113288, Oct. 2026, doi: 10.1016/J.PLANTSCI.2026.113288.

[13] W. Sun, B. Wu, C. Kong, G. Xiao, R. Huang, and H. Qin, “The role of jasmonates in plant root growth and development,” May 13, 2026, Frontiers Media SA. doi: 10.3389/fpls.2026.1836825.

[14] P. Radha Krishna and P. V. Narasimha Reddy, “Stereoselective total synthesis of (−)-decarestrictine D from l-malic acid,” Tetrahedron Lett., vol. 47, no. 42, pp. 7473–7476, Oct. 2006, doi: 10.1016/J.TETLET.2006.08.035.

[15] W. Le Goff et al., “Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes,” Cardiovasc. Diabetol., vol. 24, no. 1, Dec. 2025, doi: 10.1186/s12933-025-02624-9.

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Published

2026-07-31

How to Cite

[1]
U. Z. Hamdani, R. Yanti, and R. Riska, “PENGARUH PELARUT DEEP EUTECTIC SOLVENT ASAM DAN PROFIL METABOLIT EKSTRAK DARI KULIT BATANG SAGU (Metroxylon sagu Rottb. L)”, CJCS, vol. 8, no. 1, Jul. 2026.

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